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KMID : 0371420200980060291
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Annals of Surgical Treatment and Research
2020 Volume.98 No. 6 p.291 ~ p.298
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Differences in prognosis by p53 expression after neoadjuvant chemotherapy in triple-negative breast cancer
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Bae Soo-Youn
Lee Jeong-Hyeon
Bae Jeoung-Won
Jung Seung-Pil
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Abstract
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Purpose: Our previous studies suggested that p53-positive triple-negative breast cancer (TNBC) should be more sensitive to chemotherapy than p53-negative TNBC. The aim of this study was to determine whether p53 expression in TNBC could predict response to neoadjuvant chemotherapy and the resulting prognosis.
Methods: From January 2009 to December 2017, TNBC patients who underwent neoadjuvant chemotherapy were reviewed, including a total of 31 TNBC patients who had clinical lymph node metastasis. The status of p53 expression in patients before and after chemotherapy was evaluated.
Results: Two patients (22.2%, 2 of 9) achieved pCR in p53(+) TNBC and 4 patients (50%, 5 of 10) achieved pCR in p53(?) TNBC. There was no correlation between pCR rate and p53 expression (P = 0.350). Based on prechemotherapy p53 expression, there was no significant difference in disease-free survival (DFS) between p53(+) TNBC and p53(?) TNBC (P = 0.335). However, after chemotherapy, p53(+) TNBC had shown higher DFS than p53(?) TBNC (P = 0.099). Based on prechemotherapy p53 expression, p53(+) TNBC had better overall survival (OS) than p53(?) TNBC, but the difference was not statistically significant (P = 0.082). After chemotherapy, p53(+) TNBC showed significantly better OS than p53(?) TNBC (P = 0.018).
Conclusion: Immunohistochemically detected p53 expression in TNBC could not predict the response to neoadjuvant chemotherapy. However, p53(+) TNBC had a better OS than p53(?) TNBC in patients who underwent neoadjuvant chemotherapy.
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KEYWORD
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Immunohistochemistry, Neoadjuvant therapy, Prognosis, Triple negative breast neoplasms, Tumor suppressor potein p53
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